KI commissioned surgeon Bengt Gerdin, a professor emeritus at Uppsala University, to investigate the issue. A High-Flying Italian Surgeons Fall From Grace, https://www.nytimes.com/2022/06/17/world/europe/macchiarini-windpipe-surgeon-deaths.html. Macchiarini was turning the dream of regenerative medicine into a reality. Paolo grew close to Alexander's daughter [Investigation Discovery], He was incredibly charming, worldly smart, sophisticated, and seemed very gentle," Benita told CrimeFeed. She pushed through his appointment despite the fact that he had some very negative references and dubious claims on his rsum. Benita Alexander Before their wedding, the Almost immediately after she was fitted with a synthetic trachea in August 2012, Ms. Cetirs condition began to rapidly deteriorate, according to the courts written judgment. But even if his days had been numbered, this didnt necessarily justify what Macchiarini put him through. Next month, she will turn 57. He said yeah, so I said Lets go for it., After extracting the donors organs, you go next door and you open up Sonia and you remove the diseased trachea, and there is no going back, Dr. Genden said. Thats something that was new to us, so we need to analyze that, Lundstrm-Kron says. His recovery put Macchiarini on the front page of the New York Times. Thats what our experience of medical research leads us to suspect. The felony conviction means Macchiarini would have a hard time finding employment again in Sweden, Gerdin says. There are also plenty of desperate patients who believe because theyve been told countless times that stem cells are the cure, and who cannot wait any longer for mainstream medicine. In fact, the surgeon was still married to his wife of nearly 30 years. No one is more powerless than a patient with a disease, said Dr. Gerdin. Ms. Sein speaking with Dr. Eric M. Genden Sr., left, who developed the pioneering procedure, and Dr. Sander S. Florman, director of Mount Sinais Transplantation Institute. Chinese balloon photos Benita Alexander on attending Paolo Macchiarinis criminal trial in Sweden Alexander said she attended Macchiarini's trial for closure, seven years after she was unknowingly caught in a fraudulent romance with him, and for justice for his patients and for their families. July 21, 2022 Examined 9:54 Whats next for Russia? According to Macchiarini and his colleagues, her artificial organ was well on the way to looking and functioning liked a natural one. Every patient had another, nonlethal option, Pierre Delaere, a trachea expert at KU Leuven and an early critic of Macchiarini, said in an email to Science. Dr. Delaere developed another innovative method, performed on nine patients so far: implanting a section of donor trachea in a patients forearm for weeks until it develops blood vessels and can replace part of the patients trachea. The scandal meant theres an amazing amount of scrutiny, he said. None other than Pope Francis would officiate, and his papal palace in Castel Gandolfo would serve as the venue. Acquittal is therefore difficult to defend., But Gerdin says the verdict is not unexpected. He did this by chemically stripping away the cells of a windpipe taken from a deceased donor; he then seeded the bare scaffold with stem cells taken from Castillos own bone marrow. Paolo proposed to her on Christmas Day in 2013. Besides which, compassionate concerns dont override the basic principles of patient safety and informed consent. They reopened the case in 2020, this time charging Macchiarini on lesser counts of aggravated assault and severe bodily harm. The court ruling Thursday was in a case involving a Turkish woman named Yesim Cetir, who was the longest surviving of his patients at Karolinska. The vice-chancellor, Anders Hamsten, resigned. As studies have shown, the media often casts a positive light on stem cell tourism, suggesting that the treatments are effective and the risks low. By using a patients own cells, Dr. Macchiarini sought to rectify an age-old problem with transplants involving donated organs, which the body sometimes rejects as foreign tissue. And difficult to jump off. They and their loved ones fall victim to false hope. Miss Universe 2021 There was nothing anybody could do for these patients, said Dr. Genden, who became captivated by the problem in medical school 30 years ago after a patient with a tracheal tumor died. Surgeon Paolo Macchiarini was hailed for turning the dream of regenerative medicine into a reality until he was exposed as a con artist and false prophet. Paolo was a world-renowned surgeon who spoke six languages, mingled with the global elite, and resembled George Clooney. US Capitol By June 2013, when Paolo took Benita to Venice, Italy, for a romantic weekend, she knew she was falling madly in love. Instead, they found him guilty of negligence and the lesser charge of causing bodily harm. The plastic trachea that Yesim Cetir received disfigured her and made her last three years in life basically like torture, Bosse Lindquist, the documentarian behind the Swedish TV series The Experiment, told the Times. Also seduced by Macchiarini was former NBC News producer Benita Alexander, who met the surgeon in 2013 when she was working on A Leap of Faith, an NBC special about Macchiarini hosted by Meredith Vieira. Her colleague had sent an article that said the pope would not be in Rome, or even Italy, on the day of their wedding. Benita first met Paolo at the bar at Bostons Mandarin Oriental hotel in February 2013, when she was helping coordinate an interview for an NBC special on regenerative medicine. Please try again later. It is fitting that Macchiarinis career unravelled at the Karolinska Institute. It is unclear whether Dr. Macchiarini is still practicing medicine, but his lawyer said in May that he had no income. Even so, it wasnt until 2016 that the Karolinska Institute declined to renew his contract. But Benita stood by her man and, she said, tried to help him through a tough time. So far he has not been prosecuted in any of those countries. In court testimony, he defended himself as only trying to help desperately ill patients, and said he had the full support of KI and his colleagues. The Karolinska Institute was seduced by Macchiarini, said Dr. Gerdin. All rights reserved. Beyenes death two and a half years after the operation, caused by the failure of his artificial airway, was a grueling ordeal. By this year, Dr. Genden said, her condition had deteriorated so that if we delay further, its not going to work out.. She has since had the synthetic trachea removed. When Macchiarini accused one of them, Karl-Henrik Grinnemo, of stealing his work in a grant application, Hamsten found him guilty. Dr. Genden also transplanted the cricoid, cartilage cuffing the trachea, supplanting Ms. Seins completely destroyed cricoid. I wasnt lying exactly, just Emanuela Pecchia: Everything We Know While many in Sweden expressed disappointment at what they saw as the leniency of the sentence, given that prosecutors had asked for five years in prison, the verdict nonetheless represented the culmination of a stunning fall from grace for a once high-flying surgeon. Paolo, a visiting researcher at the prestigious Karolinska Institutet in Sweden, had shot to fame as the only doctor in the world who was able to use biological and synthetic scaffolds bathed in the patients' own stem cells for trachea transplants. There is South Koreas Hwang Woo-suk who, in 2004, falsely claimed to have created the first human embryonic stem cells by means of cloning. According to the magazine, in 2012 he was charged in Italy with attempted aggravated fraud related to alleged efforts to persuade very ill patients to undergo radical surgery at facilities where he had privileges. Science and AAAS are working tirelessly to provide credible, evidence-based information on the latest scientific research and policy, with extensive free coverage of the pandemic. Any woman would swoon for such a catch! Macchiarini, they claimed, wasnt really doing clinical research. Dr. Genden examines the new trachea by inserting a scope in a hole he left in her neck, which hell eventually close. The district court in Solna today found Paolo Macchiarini not guilty on other charges, including aggravated assault, relating to three patients he treated while working for the famed Karolinska Institute (KI). But because Macchiarini is apparently living in Spain, its unlikely to have much effect. Because immunosuppressant drugs are required to prevent rejection of the transplant, cancer patients would be eligible only if free of cancer for five years, Dr. Genden said. Probationwtf.he killed people knowing damn well that his trachea was bs! Macchiarini, meanwhile, said he did not accept the findings of the disciplinary board. And in 2014, four Karolinska University Hospital doctors filed two separate reports claiming that Macchiarinis scientific papers described exaggerated the positive results of the operations and incorrectly describe[d] the postoperative status of the patients and the functionality of the implant, the timeline says. Dr. Gerdin said Dr. Macchiarini was allowed to continue his procedures for so long because the Karolinska Institute and its hospital allowed him to do so. Ultimate Fighting Championship The first was a Vanity Fair article about his affair with Benita Alexander, an award-winning producer for NBC News. Paolo Macchiarini: Surgeon convicted for fatal Swedish - BBC The couple set a date: July 11, 2015. Colorado No one wanted to collaborate with me. The other side is flat and mobile to move air to the lungs. He was handsome, suave, and a charmer. Its actually meaningless for him, Gerdin says. Help News from Science publish trustworthy, high-impact stories about research and the people who shape it. There Was Nothing Anybody Could Do for These Patients. Now There Is. Only three are still alive as of September 2020. Dressed in a white lab coat or in surgical scrubs, with his broad, handsome face and easy charm, he certainly looked the part. Prior to this, he was regarded as a pioneer in the field of regenerative medicine using both biological and synthetic scaffolds seeded with patients own stem cells as trachea transplants. That drama began about a decade ago when Dr. Paolo Macchiarini, working at Swedens famed Karolinska Institute, garnered headlines and accolades for replacing damaged tracheas with plastic tubes seeded with patients stem cells that he cultivated in devices called bioreactors. 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She had already spent $10,000 on engraved invitations made for a guest list that included the Obamas, the Clintons, Vladimir Putin, and Elton John. He was eventually dismissed from Karolinska. But that, and the fact that he had multiple cell phones for different countries, she chalked up to his demanding job and constant international travel. However, behind closed doors, Dr. Macchiarini was hiding a secret the procedures were not working. Most protagonists on medical dramas are modern-day heroes. Disgraced Italian surgeon convicted of criminal harm to stem cell patient. Her ex-husband John was dying of cancer. But it did not work, and a court in Sweden has found him criminally liable for the harm inflicted on a patient. He is still licensed to practice medicine in Europe. Its fascinating to rewatch as a lesson on how not to report on medical science. Karolinskas leadership expected big things from their superstar, things that would bring prestige and funding to the institute. To some extent, they believed Macchiarini because he told them what they wanted to hear. All rights reserved. For other cases, though, doctors say the approach seems promising. A good example is the NBC documentary A Leap of Faith. In place of clinical data, there are gushing testimonials. Paolo then came across Andemariam Teklesenbet Beyene, a man from Eritrea who was training to be a doctor when he got diagnosed with cancer. First Successful Trachea Transplant a Medical Milestone - The Chief judge Bjoern Skaensberg said the court agreed that Macchiarinis operations were not consistent with science and proven experience, but the court determined that two of the interventions were justifiable.. She received another In early 2014, four Karolinska doctors defied the reigning culture of silence by complaining about Macchiarini. The secret sauce in his approach, he said, is transplanting not just the donor trachea but also its attached esophagus (food tube), thyroid gland and thyroid arteries. Macchiarinis lawyer declined to comment to Swedish media today about whether his client would appeal. Award-winning documentary-maker Benita Alexander was swept off her feet by renowned Italian doctor Paolo Macchiarini in 2013 while she was working on a story about his pioneering medical work. Benita Alexander and Paolo Macchiarini in Venice, Italy [Investigation Discovery]. It relieved a little bit of burden from him.. North Carolina Reports of their success always seemed like hot air to him. It showed department heads and colleagues that they should give Macchiarini special treatment.He could do pretty much as he pleased. Donald Trump Four of Macchiarinis colleagues at KI, including Corbascio, filed official complaints in 2014 charging that several papers describing the surgeries deliberately left out serious complications in the patients. In 2018, KI finally released the findings of its second investigation, which confirmed he had committed misconduct. Vanity Fair also later discovered that several of Paolo's other statements were false, including his claims about having been an associate professor at the University of Pisa. But, he added, Its an indirect technique. It takes time and can replace only the tracheas halfpipe side, so its not a complete tube.. These included Harriet Wallberg, who was the vice-chancellor of the Karolinska Institute in 2010, when Macchiarini was recruited. Plus: A Chicago mother is arrested in connection to the murder of her 6-year-old son; the convicted killer Robert Durst dies at age 78; Theranos founder Elizabeth Holmes sentencing date is set; and an LGBTQ+ rights movement hero is found dead in a Florida landfill.
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