I had my dog on it and the price was pretty steep. The most common practical starting dosage for many cats is of the 5.4mg tablet, or 2.7mg. Nobody wants to be itchy and constantly scratching. But I had my mare tested last year, she also came up allergic to some foods (flax being one) for which I was told serum was not an option. ACVIM, a Florida-based large animal internal medicine specialist with an interest in respiratory disease. Bursatti, Leeches) in Dogs, Cats and Horses. The dosage will depends on your dog's weight. In the first 2 randomized, double-blinded, placebo-controlled clinical trials, it was shown that oclacitinib, given at a dose of 0.4 to 0.6 mg/kg q12h, induced a rapid reduction in pruritus and treatment success in 62.3% to 67% of treated cases within 7 to 14 days.7,8 Treatment success was based on reductions from baseline of at least 2 cm on the owner-assessed visual analog scale and at least 50% on the clinicians Canine Atopic Dermatitis Extent and Severity Index (CADESI-02). I was one of the veterinarians involved in early field trials for Apoquel in horses. Olivry T, Banovic F. Treatment of canine atopic dermatitis: time to revise our strategy? Apoquel can only be obtained with a prescription; it is available as film-coated tablets and chewable tablets in different strengths to cover a range of dog weights. Noli C, Matricoti I, Schievano C. A double-blinded, randomized, methylprednisolone-controlled study on the efficacy of oclacitinib in the management of pruritus in cats with nonflea nonfood-induced hypersensitivity dermatitis. Apoquel For Dogs: Safety, Dosage, Side Effects & More - Veterinary Place For more information, please see the full Prescribing Information. Since some horses have both "types" of asthma, you may need to try a stall without bedding, or experiment with different types of bedding. Also. That's why dosage is usually tapered down to the lowest effective dose. It is no surprise we see this omega-3-rich plant with anti-inflammatory and antioxidative properties in many skin and allergy supplements. In a 2019 study Radwanski et al. The steroids are usually given orally, but we may want to start with injections for a week or so in severely affected horses. Zoetis Until recently, glucocorticoids (systemic and/or topical) and cyclosporine have been considered the most effective symptomatic treatment options to manage atopic dermatitis.5 Oclacitinib is now also an effective option (BOX 1). Fukuyama T, Ganchingco JR, Bumer W. Demonstration of rebound phenomenon following abrupt withdrawal of the JAK1 inhibitor oclacitinib. Thereafter the dose should be reduced to once daily for maintenance. Your veterinarian also may use dexamethasone in high doses in emergencies for anaphylactic reactions, spinal cord trauma or shock. A blinded, randomized clinical trial comparing the efficacy and safety of oclacitinib and ciclosporin for the control of atopic dermatitis in client-owned dogs. 14. Repeated oral dose tolerance in dogs treated concomitantly with ciclosporin and oclacitinib for three weeks. Binding of these cytokines to their receptors activates the JAK-STAT (signal transducers and activators of transcription) pathway, which leads to further cytokine production. Like most treatments, this medication will not be successful in every horse, but if it does work, it avoids the risks associated with steroids. 3. Apoquel starts working within 4 hours of administering the first dose and controls itching within 24 hours. All rights reserved. In many cases, symptomatic therapy alone with drugs such as oclacitinib is insufficient to control allergies long-term. Join us as we interview leading equine researchers from the University of Kentucky, Problem Solver Series: How to Control Nuisance Birds on Horse Properties. Binding of these cytokines to their receptors activates the JAK-STAT (signal transducers and activators of transcription) pathway, which leads to further cytokine production.1 In recent studies, IL-31 has been shown to play an important role in pruritus, and elevated serum levels of IL-31 have been found in many atopic dogs.2, There are 4 JAK families in mammals: JAK1, JAK2, JAK3, and TYK2. Oclacitinib preferably inhibits JAK1 and, to a lesser degree, JAK3, resulting in decreased activity of JAK1-dependent cytokines involved in allergy and inflammation (IL-2, IL-4, IL-6, and IL-13) as well as pruritus (IL-31).4. not random, very relevant and helpful! The anti-inflammatory/immunosuppressive response is confined almost exclusively to the lungs, avoiding a bodywide effect, says Fultz. Specifically, studies in cats have used the following dosage: Initially, doses ranging from 0.4 to 1.2 mg/kg body weight, twice daily, for 24-28 days. Food allergies in particular you cant always do the serum for. Long term itch reduction. Many of these cytokines bind to cytokine receptors that have JAK enzymes associated with their cytoplasmic portion. At that point, the treatment can be changed to oclacitinib. Definitely less than a horse lol but 1.5 16mg tabs a day is $$. Apoquel is a prescription dog allergy medicine used for the control of itch associated with allergic dermatitis and control of atopic dermatitis in dogs 12 months and older. Most commonly, horses develop an allergy to the saliva of biting insects (e.g., gnats, black flies, stable flies, horn flies) known as, While relatively safe for use in most horses, these potent anti-inflammatory drugs can cause a serious potential side effect in some individuals: an increased risk of developing the debilitating hoof disease. Use code GOODRX20 Sponsored by Apoquel | Horse and Hound Forum Assuming you cannot contact your vet: For hives or possible allergic airway disease (heaves), for a 1000 lb horse, give 5-10 tabs of 25mg diphenydramine crushed up and mixed in water and dosed in a syringe orally (by mouth). Ive used it on a couple of mine, and I also have some friends who have done it. On the label for dogs, Apoquel is used every 12 hours for the first 14 days of use, then backed down to dosing every 24 hours once a day. Apoquel from 0.90 - VetUK Cosgrove SB, Wren JA, Cleaver DM, et al. Efficacy of oclacitinib (Apoquel) compared with prednisolone for the control of pruritus and clinical signs associated with allergic dermatitis in client-owned dogs in Australia. Unlike steroids, the drug has minimal impact on the immune system. 3. Serious side effects include seizures, abnormal breathing, incoordination, muscle tremors, and coma. Skip to Article Content; Skip to Article Information; Search within. This gives you the total number of milligrams for the dose for your horse. Apoquel comes in tablet form only. Im not dealing with food allergies but both the company and the vet did not recommend allergy shots for my mare. Apoquel Dosage in Dogs Apoquel tablets for dogs comes strengths of 3.6mg, 5.4 mg and 16mg of oclacitinib per tablet. I am not saying it is a cure all, but that and some generic Zyrtec make my mare a whole lot more comfortable. One of the things the trials found on using apoquel with horses is that they need a relatively small dose. This product is a hand-held device that administers an anti-inflammatory mist into the horses nostril. Preventing bites is key, because itching-inflicted injury to hair follicles and skin can take months to heal. The drug targets pro-inflammatory proteins, called cytokines, responsible for itching and inflammation, relieving signs of skin allergies. The powerful network of cells and antibodies known as the immune system can recognize dangerous invaders and disarm them before they hurt the host. New Approach to Equine Asthma Treatment Vet Dermatol 2018:29:371 (abstract). Interleukin-31: its role in canine pruritus and naturally occurring canine atopic dermatitis. Copyright 2023 Today's Veterinary Practice Web DesignbyPHOS Creative. Apoquel has not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporines. Vet Dermatol 2016;27(1):22-e7. Pros and cons of oclacitinib therapy. Fultz adds that over time this process teaches the immune system to tolerate exposure to substances it previously considered irritating. Prednisone for Dogs, Cats, and Horses - Wedgewood Pharmacy Repeated oral dose tolerance in dogs treated concomitantly with ciclosporin and oclacitinib for three weeks. Rarely, dogs on Apoquel develop new skin masses; however, a long-term study found no association between Apoquel and the development of malignant cancer. Vet Dermatol 2013;24(6):587-597, e141-142. There are a few medication protocols for horses with Equine Asthma. Apoquel is a prescription medication used to treat itching and inflammation in dogs. Oclacitinib (APOQUEL) is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. Please select your state below. Six adult horses with a mean weight of 528 kg were . Is it horrendously expensive? A follow-up study assessed the long-term safety, efficacy, and quality of life of oclacitinib-treated dogs. Apoquel Oclacitinib Used for Pet Meds MORE expand_more savings GoodRx lowest price $75.90 (Save -22%) local_offer Avg retail price $62.49 medication Availability Brand only Get 20% off your first order with code GOODRX20 Shop Apoquel at America's #1 Pet Pharmacy for the best pet prescription medications online! Vet J 2016;207:29-37. The most common side effect is lethargy, dry mouth, and urinary retention. . Even though the drug is currently labeled for use in dogs (with allergic dermatitis), initial studies show that horses absorb it well, Fultz says. For this first stretch, thats not going to get me too far since I need the loading dose up front. Zyrtec: The human antihistamine may be beneficial in a small proportion of horses with Equine Asthma. Equine Regenerative Therapies for Managing Arthritis in Horses, Infographic | 12 Smart At-Home Biosecurity Practices for Horse Owners, Infographic | How To Keep Your Horses Joints Healthy. Yamaoka K, Saharinen P, Pesu M, et al. 21. 26. 16. Vet Dermatol 2019;30(2):110-e30. 23. The only FDA-approved equine PSGAG. 18. 1800PetMeds is your online pet store offering discount prices on pet supplies, medications, vitamins and supplements for your pet. Skin allergies can also cause pruritus (itching) and associated hair loss. Previcox is an FDA-approved non-steroidal anti-inflammatory (NSAID) prescription medication used in dogs to treat pain and inflammation associated with osteoarthritis and for the control of postoperative pain and inflammation associated with soft-tissue and orthopedic surgery. Several reports of successful use of oclacitinib to treat other diseases have been published. In atopic dermatitis, it is mainly mediated by a large group of proinflammatory and proallergic Th2 cytokines (e.g., interleukin [IL]-4, IL-5, IL-10, IL-13, IL-31). In more severe cases, Apoquel can be given twice per day. Apoquel For Dogs: Dosage, Side Effects, and Natural Alternatives Dr. Patrick Hensel is a 1996 graduate of the University of Bern, Switzerland. Most horses in our area of North Carolina are "Summer-Pasture-Associated" asthma patients, so we recommend starting yearly treatment or management in March or April. Her lifelong love of horses motivated her to adopt her college care horse, Claire, upon graduation. 2022 Zoetis Services LLC. 2: The Barn and Pasture: Horses with Summer-Pasture-Associated disease usually have less symptoms when kept in the barn during the warmer months. In the first pilot study, oclacitinib (0.4 to 0.6 mg/kg, q12h for 14 days, then q24h for 14 days) was used to treat pruritus in cats with non-flea, nonfood-induced hypersensitivity dermatitis. Gonzales AJ, Bowman JW, Fici GJ, et al. I hear the result have been spectacular. Many medications are available to help manage your horses allergies, some of which are best used as preventives in sensitive horses. 15. . Why were losing our horse doctors and how to begin solving the problem. Hay naturally contains microscopic fungal spores, plus bacterial and dust components that horses inhale as they eat, explains Lisa Fultz, DVM, MS, Dipl. It is most risky in horses that have metabolic disease like Equine Metabolic Syndrome (insulin resistance), PPID (cushings), or those that are overweight. Apoquel can be administered with or without food. Dexamethasone for horses: Uses, Dosage & Side Effects - Wedgewood Pharmacy This drug has been used in dogs with some pretty fabulous results. These might include antihistamines such as cetirizine, which you can buy over the counter as Zyrtec from any drug store or pharmacy, or hydroxyzine, which requires a veterinary prescription. Cosgrove SB, Wren JA, Cleaver DM, et al. And some can got a lower dose or a further spread out dose. The downside is that it can cause laminitis and can suppress their immune system. FALL 2019. m. Editor: Norma White-Weithers, MS, DVM, DACVD Veterinary Allergy & Dematology Consultant, Baldwin, NY 11510 Work: 646-329-4719 . Avoid storing hay in the same barn as sensitive horses, since hay particles and spores can be irritating, even from a distance and even if they are not visible in the air. Gadeyne C, Little P, King VL, et al. Both can be very serious. Therefore, it is important to get your veterinarian involved right away. If your horse has "classic" RAO, he may have more difficulty in the barn, and need to be kept outside 24/7.3: The Supplements: Studies have shown that horses with Asthma benefit from supplements with Omega 3 fatty acids. Im hoping those are things I can stop giving, so that will help some with overall cost. As a result, muscles relax and cause heavy sedation, notes DailyMed. Vercelli A, Cornegliani L. Use of oclacitinib for the treatment of acral lick dermatitis in a dog: a case report. Interleukin-31: its role in canine pruritus and naturally occurring canine atopic dermatitis. Shes on 5 pills once a day for 7 days, after that we will drop to every other day, and then see how far we can space it out. Levy BJ, Linder KE, Olivry T. The role of oclacitinib in the management of ischaemic dermatopathy in four dogs. Freedom of Information Summary NADA 141-345 Vet Dermatol 2015;26:134 (abstract). If the horse is allergic to any of them, his immune system elicits a response, and a hive forms at the injection site. Simpson AC, Schissler JR, Rosychuk RAW, et al. There are 4 JAK families in mammals: JAK1, JAK2, JAK3, and TYK2. Oclacitinib preferably inhibits JAK1 and, to a lesser degree, JAK3, resulting in decreased activity of JAK1-dependent cytokines involved in allergy and inflammation (IL-2, IL-4, IL-6, and IL-13) as well as pruritus (IL-31). This content is intended for counseling purposes only. Apoquel. The results are problematic. Ortalda C, Noli C, Colombo S, et al. Equine Drug Dosage Calculations | Equimed - Horse Health Matters